BIOL 1082 Lecture Notes - Lecture 21: Fetus, Multiple Sclerosis, Immunity (Medical)

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19 Sep 2017
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Defenses against pathogens ii (reading: concepts: 43. 3-43. 4 in textbook: distinguish between the roles of antigen-presenting cells, b-cells, plasma cells, helper t-cells, and cytotoxic t-cells, and how they carry them out. Antigen-presenting cells are the cells responsible for presenting the antigen for recognition. Antigen presentation is a process in the body"s immune system by which macrophages, dendritic cells and b-cells capture antigens (w/ mhc on their surface), then enable their recognition by t-cells. The secretion of antibodies by b-cells is the hallmark of the humoral immune response. Stimulated by both an antigen and cytokines, the b-cell proliferates into memory b-cells and anti-body secreteing plasma cells. A b-cell presents only the antigen to which it specifically binds. When an antigen first binds to receptors on the surfaces of a b-cell, the cell takes in a few foreign molecules by receptor-mediated endocytosis. The class ii mhc protein of the b- cell then presents the antigen fragment to the helper t-cell.

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