BMB 420 Lecture Notes - Lecture 7: Apoptosis, Antibody, Cytotoxic T Cell

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Bernard
Sepsis Reading
3/21/18
De-escalation of antibiotics during sepsis infection helps to prevent antibiotic resistance by
narrowing antibiotics and decreasing the dosage.
-Post sepsis, you have an increased risk of infection due to widespread damage.
-Neurological dysfunction is also seen after infection is eradicated.
-S. aureus and Streptococcus pyogenes are both beta hemolytic and lyse red blood cells.
-pseudomonas is very hardy and good at forming biofilms. Can grow in distilled water and dial
soap.
-Most sepsis is caused by pneumonia. Many different organisms can cause pneumonia, so the
elderly and infants are more likely to acquire sepsis. Hospital acquired pneumonia is very
common.
-19 million cases a year worldwide.
-10% of ICU cases in US is sepsis.
Edema: inflammation due to acute inflammatory response (margination and diapedesis and
shrinking of capillaries). White blood cells want to be where the injury is to heal it.
-Shrinking of epithelial cells allows blood to seep past and invade the tissue, causing swelling.
Histamine = vasodilation and increased blood flow and reduced blood pressure (hypotension).
Fever: Lipid A, endotoxin causes the fever. Lipid A is a part of lipoproteins.
Leukocytosis and Leukopenia: determines causative agent. Lekocytin lyses white blood cells.
Coagulation abnormalities:
When an infection gets into the bloodstream, the bacteria is suddenly there
and the whole body gets an inflammatory response. Body will stop blood flow to affected area,
which is everywhere and blood clots form though-out all the capillaries and petichiae DIC
(disseminated intravascular coagulation). Can cause blood flow to not reach lateral sides of body.
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Document Summary

De-escalation of antibiotics during sepsis infection helps to prevent antibiotic resistance by narrowing antibiotics and decreasing the dosage. Post sepsis, you have an increased risk of infection due to widespread damage. Neurological dysfunction is also seen after infection is eradicated. S. aureus and streptococcus pyogenes are both beta hemolytic and lyse red blood cells. Pseudomonas is very hardy and good at forming biofilms. Can grow in distilled water and dial soap. Many different organisms can cause pneumonia, so the elderly and infants are more likely to acquire sepsis. 10% of icu cases in us is sepsis. Edema: inflammation due to acute inflammatory response (margination and diapedesis and shrinking of capillaries). White blood cells want to be where the injury is to heal it. Shrinking of epithelial cells allows blood to seep past and invade the tissue, causing swelling. Histamine = vasodilation and increased blood flow and reduced blood pressure (hypotension).

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