BMB 440 Lecture Notes - Lecture 7: Lipopolysaccharide, Gastritis, Gout
2 Mar 2018
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Document Summary
Antimicrobial peptides (in phagocytes and secreted by epithelial cells). These work in combination (e. g. proteases and amps, phox and inos) to degrade and kill microbes. Destruction occurs through enzyme degredation, antimicrobials proteins, and toxic effects of reactive oxygen and reactive nitrogen species (ros and rns). Type 1 interferons (potent antiviral activity): prevents neighboring infection. Cytokines (inflammatory il-1, tnf-a, and il-6): attract other immune cells. Antigen presentation pathway: promote a restrictive environment at infection site. Induced by proinflammatory cytokines (il-1, tnf-a, and il-6) Apr involves: increased synthesis/ secretion of antimicrobial proteins from the liver. Liver acute phase proteins activate other processes that help eliminate pathogens. Nk cells are lymphocytes with innate immune functions. Express a set of receptors for self proteins induced by: Activated nk cells perform one of two functions: Produce cytokines that induce adaptive responses against the altered self cell. Regulation and evasion of innate and inflammatory responses. Defects in prrs and signaling pathways increase susceptibility to infections.
