IMM250H1 Chapter Notes - Chapter 4: Antiparasitic, C3B, Mast Cell
Document Summary
Released by one cell, soluble proteins, bind to receptors. Interferons: chemokines: il-1b, il-6, il-18, and tnf, growth factors. Monitors leukocyte exiting from blood vessels: selectins: cams expressed by endothelial cells. Neutrophil, basophil, eosinophil, monocyte (dendritic cell, macrophage, mass), nk cell: cellular mediators: neutrophils, macrophages, lymphocytes, humoral mediators: complement, antibodies. Increases vascular permeability to igg complement and for cells to tissues. Cxcl8 (ir-8) (chemokine) recruits neutrophils, basophils, & t cells to infection site. Dc main antigen presenting cell for na ve t cells (adaptive immunity) Phagocytosis only good for small and extracellular microbes: recognition & attachment, engulfment, killing and degradation by ros and no. Rns reactive nitrogen species (needs inos to make) Nb: these two are made by nadph oxidase and kill microbes by respiratory burst. Basophils (granulytes: not common, anti-parasitic, make lots of histamine (in allergic responses) Eosinophils (granulocytes: parasitic infections and allergy.
