PSY 201 Lecture Notes - Lecture 16: Morris Water Navigation Task, Retrograde Amnesia, Long-Term Potentiation
8 Feb 2018
School
Department
Course
Professor
Document Summary
Causes insertion of additional glutamate receptors into postsynaptic membrane. Causes structural changes of the synapse that lead to the create of new synapses. Causes creation of the neuromodulator nitric oxide which diffuses to presynaptic neuron and enhances glutamate release. Evidence for role of ltp in learning. Ltp prominent in brain areas involved in learning. Drugs that block ltp also impair learning abilities. Drugs that facilitate ltp also enhance learning abilities. Mice genetically-enhanced to have more nmda receptors have better learning abilities (doogie mice) Tradeoff: doogie mouse are smarter, but also more. Morris water maze: susceptible to chronic pain. Environmental cues in proom provide information that permits animals to orient themselves in space and learn the location of a hidden platform. Medial temporal lobectomy: h. m. underwent surgery for severe seizures in 1953 at age 27. Bilateral removal of medial temporal lobe, including hippocampus. Almost total loss of ability to encode new long term memories but preserved short term memory.
