BIO 198 Lecture Notes - Lecture 37: X-Inactivation, Dosage Compensation, Insulin-Like Growth Factor 2
22 Nov 2016
School
Department
Course
Professor
Document Summary
Epigenetic inheritance: changes to gene expression that do not involve in gene sequence; these modifications can be reversible (turn off and on and changing modifications to heterochromatin, etc. ). X chromosome inactivation and position effect variegation (near the boundaries are not precise). Modifications: methylation of the dna and change ability to proteins to bind there. Histones have large number of lysine residues and are positively charged to bind to negatively charged dna and increase compaction of dna. Acetylation: add an acetyl group to lysines on the histones with acety coa and positive charge is then eliminated and this modification is associated with the loosening of chromatin compaction. Dna wraps around the core histone proteins and these tails that come off the tails are where the modifications occur: lysine = lys = k. Methylation: mono, di and tri methylation modifications to lysine residues and depends what residues are methylated.
