BIOL 115 Lecture Notes - Lecture 16: Reproductive System, Trachea, Triiodothyronine

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Thyroid gland, parathyroid glands, pancreas, pineal gland, reproductive. 2 lobes on either side of trachea attached by isthmus. Glandular tissue is arranged in follicles, the middle has colloid substance (mixed substance) Production and secretion of thyroid hormones start in colloid. Follicular cells surrounding it uptake iodide (i-), which accumulates in colloid. I- is oxidized and attached to protein in colloid called thyroglobulin. 2 dits sticking together produce tetraiodothyronine aka thyroxine, t4. 1 mit + 1 dit = triiodothyronine aka t3. Bound to bigger molecule means no action, but once they separate and are secreted into the bloodstream, become active. Upon tsh stimulation, follicular cells take in some colloid. Hydrolyze t3 & t4 from thyroglobulin (thus making t3&t4 free to be secreted from follicular cells. This increases the basal metabolic rate by promoting the glucose oxidation (first step of glycolysis) Increases blood calcium level when it drops by acting primarily on: Bone: stimulates osteoclasts (secrete acids & enzymes to dissolve.

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