BIOL 115 Lecture Notes - Lecture 25: Renal Function, Ultrafiltration, Basement Membrane

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25: glomerular ultrafiltrate, reabsorption of salt & h2o, pct, renal. Basement membrane negatively charged proteins; prevent passage of negatively-charged plasma proteins (globulins & fibrinogens) Slit diaphragm - filters last of what we don"t want to cross. Glucose, amino acids, saltslots of h2o get across membrane. Hydrostatic (out) through capillaries, hydrostatic pressure inside capsule, capsular hydrostatic back into) Net outward pressure, so shows filtration aka urine formation. Glomerular filtration rate -> volume of ultrafiltrate produced/minute. Total blood volume filtered out every 40 min. * most of the filtrate will be reabsorbed. Filtrate captured in glomerulus capsule, then goes to pct. Well hydrated = lots of h2o to spare. 400 ml/day -> obligate h2o loss from urine. This is to ensure excretion is diluted enough. Bigger concentrate than that = beginning of kidney stones. Proximal convoluted tubules: (pct): tubular reabsorption (of na+[h20], cl, amino acids, glucose) occurs here. Total [solute] is approximately equal to plasma [solute]

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