PSYCH 202 Lecture Notes - Lecture 3: Excitatory Postsynaptic Potential, Inhibitory Postsynaptic Potential, Axon Hillock
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Calcium acts as a second messenger (activates docking proteins that allow vesicles to fuse to proteins that allow exocytosis) Binding sites: place where neurochemical will bind (lock-and-key analogy). Ligand: any molecule that can bind to a binding site and activate a receptor. Endogenous molecules: made within the body, acts on receptors. Exogenous molecules: made outside of the body (aka drugs) Ligand-gated ion channels open in response to a neurochemical activating a receptor. Voltage-gated ion channels open in response to a specific membrane potential. Come from movement of ions across the membrane. Epsps (excitatory post-synaptic potential): depolarizing- move sodium into inside of cell (na+) Ipsps (inhibitory post-synaptic potential): hyperpolarizing- potassium moves out of cell, chloride goes in (k+, cl-) How do psps relate to action potentials? the. Epsps provide the depolarization that may add up to the threshold of excitation at axon hillock.
