PSYCH 202 Lecture Notes - Lecture 28: Major Depressive Disorder, Prefrontal Cortex, Frontal Lobe
14 Feb 2018
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Hypofrontality: there is less activity in the prefrontal cortex for those who have schizophrenia, reduced prefrontal activity in sch patients compared to controls. Some studies have shown hypofrontality in 1st degree relatives (to a lesser degree) - possible predisposition. Chemistry: neurotransmitters: dopamine (too much?, still predominant theory about neurotransmitters and sch, glutamate (too little), glu hypothesis developed from recreational drug use symptoms. Dopamine hypothesis: positive symptoms of schizophrenia may be caused by da overactivity, antipsychotic drugs (da antagonists) diminish or eliminate positive symptoms, some recreational drugs (da agonists) can induce sch-like psychosis (e. g. amphetamine, cocaine) Which of the following is associated with positive symptoms of schizophrenia: too much da in striatum, too little da in pfc (associated with negative symptoms) Which of the following brain differences is not associated with schizophrenia: not, smaller neurons in frontal lobe. Is: enlarged ventricles, decreased frontal lobe activity, excessive gray matter loss.
