BIS 101 Lecture Notes - Lecture 15: Epistasis, Haemophilia, Zygosity

25 views2 pages

limebadger340

7 Nov 2016

School

Department

Course

Professor

For unlimited access to Class Notes, a Class+ subscription is required.

Document Summary

Clicker questions: hemophilia in the royal family is an x-linked recessive trait. Pedigree of hemopheilia in the royal family shows the mode of inheritance to be x-linked recessive because most men have the disease, if it was mitochondrial all kids would have it. Branching in corn (shaded or not shaded) 9:3:3:1 phenotypic ration (no epistasis) only when no interaction. Epistasis many loci, genes that regulate other genes are likely in epistasis: effects of genotype at one locus depend on the genotype at another locus. Flower color phenotype white locus epistatic to m locus (w stands on m locus and (cid:862)kicks(cid:863) it) Suppressor mutant that suppresses effects of other mutant making it wt. Synthetic lethals two mutants at different genes each non-lethal but together lethal. If unsure if it is recessive epistasis or incomplete dominance, you can use stats to help (chi-squared)

Related Questions

In humans, hemophilia is a sex linked trait. Females can be normal, carriers, or have the disease. Males will either have the disease or not (but they wonât ever be carriers)

X H X H = female, normal / X H Y = male, normal

X H X h = female, carrier

X h X h = female, hemophiliac / X h Y= male, hemophiliac

Show the cross of a man who has hemophilia with a woman who is a carrier. What is the probability that their children will have the disease? __________

7. A woman who is a carrier marries a normal man. Show the cross. What is the probability that their children will have hemophilia? What sex will a child in the family with hemophilia be?

8. A woman who has hemophilia marries a normal man. How many of their children will have hemophilia, and what is their sex?

The following question is a sex-linked trait. Review the patterns of inheritance of sex-linked traits before answering the following questions. Make sure to indicate chromosomes and alleles in your answers when necessary.

Hemophilia is a caused by a recessive mutation found on the X chromosome in humans. The recessive allele (X^h) is associated with abnormal blood clotting (hemophilia), while the dominant allele (X^N) causes normal blood clotting.

A man with normal blood clotting and woman who is heterozygous are going to have a child. What is the probability of an offspring who is a carrier of hemophilia, and if so, the sex(es) of the offspring?

A. Chances are 25% of a son who is a carrier

B. There is no chance of an offspring who is a carrier

C. Chances are 50% of either a son or a daughter who is a carrier

D. All offspring, male or female, will be carriers

E. Chances are 1 in 4 of a daughter who is a carrier

2. Two fruit flies, one with red eyes and one with white eyes mate and have an offspring with white eyes. Having red eyes is a dominant trait (R) while white eyes (w) is recessive. Based on this information, what must be the genotypes of the parental white-eyed fruit fly and the parental red-eyed fruit fly?

A. Red-Eyed fruit fly: Rw

White-eyed fruit fly: ww

B. Red-Eyed fruit fly: RR

White-eyed fruit fly: wR

C. Red-Eyed fruit fly: R

White-eyed fruit fly: w

D. Red-Eyed fruit fly: rr

White-eyed fruit fly: wr

E. Red-Eyed fruit fly: RR

White-eyed fruit fly: ww

1) A sex-linked recessive allele of gene B is the subject of this problem. Assume that a man with the recessive allele marries a woman with a normal phenotype. The woman's father had the recessive allele too. What is the probability that the couple will have a daughter with the recessive phenotype?

2)Albinism is inherited as a simple recessive trait. If a woman and her husband are both heterozygous for albinism then what is the probability that their first five children will have these phenotypes? Child 1 - albino; child 2 - normal; child 3 - normal; child 4 - albino; child 5 - normal?

3)Glucose-6-phosphate dehydrogenase deficiency (G6PD) is inherited as an X-linked recessive gene in humans. A woman whose father suffered from G6PD marries a normal man. (a) What proportion of their sons is expected to be G6PD? (b) If the husband were G6PD deficient would you change your answer in part (a)?

azuremouse752

BIS 101 Lecture Notes - Lecture 15: Epistasis, Haemophilia, Zygosity

Document Summary

Get access

Related Documents

BIS 101 Study Guide - Comprehensive Midterm Guide: Gene Expression, Single-Nucleotide Polymorphism, Quantitative Trait Locus

BIS 101 Chapter Notes - Chapter 3: Organelle, Product Rule, Dihybrid Cross

BIOL 142 Lecture Notes - Lecture 9: Consanguinity, Y Chromosome

Related Questions