ETX 20 Lecture Notes - Lecture 19: Microcystis, Acute Kidney Injury, Chromatography
1 Jul 2016
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Document Summary
Apply fundamental concepts of pharmtox to real life situations ( translation ) relevant to animal and human health. Explain the know-how needed to reach a diagnosis and/or come to conclusions for prevention strategies. Oleander: ornamental shrub, white to dark pink. Oleander inhibits na+/k+ atpase in cells, causing cardiac arrest. All parts (dried and fresh) are toxic. Minimum lethal doses: ~5 leaves or less. Dog was discharged after 8 days and fully recovered in 4 weeks. Two days later, it ate leaves again so it went to the vet hospital. Suddenly acting abnormal, painful abdomen, refused to eat, vomit in pool. Animal had renal disease and was very dehydrated. High winds were noted during the previous evening and many leaves were in the pool. Hay was examined, dried oleander was found in the hay (10% of the hay was oleander) Two died, and the third who died was tested and oleandrin was found in blood.
