NPB 101 Lecture 3: Lecture 3

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Plasma membrane of all living cell has a membrane potential. Separation of opposite charges across plasma membrane. Due to difference in: concentration, charge, permeability of key ions. Resting membrane potential: constant membrane potential present in cells of, non- excitable tissues, excitable tissues, when they are at rest. Nerve and muscle cells: excitable cells (some force that cell recognize and responds to, have ability to produce rapid, transient changes in their membrane potential when excited. = -60 mv: there must be channels to achieve diffusion so molecules can travel in and out. An electrical gradient pulls k+ back into the cell (icf negative vs ecf) A concentration gradient pushes k+ out of the cell (high to low[k+]) Nernst potential: eion = (61/z) x log[ion]o/[ion]i, z = ion charge, [ion]o = ion ecf concentration, [ion]i = ion icf concentration, ek = 61 x log(5mm/150mm)

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