NPB 101 Lecture 28: Lecture 28
11 Nov 2017
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Document Summary
Atrial natriuretic peptide (anp; from the atria) and brain natriuretic petide (bnp; from the ventricles) are released in response to high blood pressure/volume/nacl load. Smooth muscle of afferent arterioles increased gfr. Inhibits sympathetic nervous system to reduce cardiac output and peripheral resistance. Glucose and amino acids are actively reabsorbed in the proximal tubule by na+ - dependent by specific symport carriers (e. g. sodium-glucose linked transporter; sglt) across the tubular membrane into the cell (= secondary active transport). Glucose then diffuses across the basolateral tubular membrane via glucose transporters (glut) (= facilitated diffusion). Glucose reabsorption is efficient and complete, but the number of sodium-glucose symporters is finite tubular maximum. Hydrogen ion secretion is important in acid base. Renal h+ is secretion in the proximal tubules. Renal h+ can be either secreted or reabsorbed by special intercalated cells" in the distal and collection tubules depending on the acid balance in the plasma. Organic anion and cation secretion is controlled by tubular secretion:
