NPB 113 Lecture Notes - Lecture 7: Stroke Volume, Skeletal Muscle, Sarcomere
3 Apr 2021
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I cross bridges yahoo. si/i#inmmaainuo , bridges , c- interference length of muscle. Sarcomere ~ 2 to 2. 4 m meters in length large n overstretching muscle. " as more blood fills the ventricles stretch ventricles ( t length) force generated will be greater. Small edv smaller force: large edv larger force. As ventricular volume t more cross bridges form: geometric advantage : as ventricular volume t thick and thin filaments position closer to each other. Ted v thick filament thin filament smaller distance. More likely to form more cross bridges: as ventricular volume t changes affinity of troponin, (th c) to cart. Increases affinity to cast allows formation of cross bndaes. Preload ( ventricular preload ) : volume in ventricles prior to ejection ( edv) Can change depending on how much blood fills ventricles during diastole. With t preload ( edv ) the contractile force will increase stroke volume increases. Small preload ( small edv) weaker contractions stroke volume decreases.
