NPB 113 Lecture Notes - Lecture 26: Bronchiole

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At frc the cumulative force is zero. Only small amount of energy 1 pressure needed to change volumes during normal breathing. " beyond 80 - l - tlc large amount of energy ! pressure required to expand the lung. Need to exert positive force on. both lung and chest wall. Regional differences in pip lead to differential lung inflation. On average pip = 756 mmhg at frc. If alveolus larger ( already stretched out ) , requires larger trans mural force to inflate it. " if alveolus smaller , requires less force to inflate it (cid:8869) less elastic recoil in smaller alveoli. 1mm has small alveoli ( bottom ) small elastic recoil large elastic recon. During an inspiratory effort , preferentially inflate smaller alveoli at the bottom of the lung. Then inflate medium - sized alveoli , then inflate larger alveoli p p= 750 mmhg grab. ee . During normal expiration: palm = 760 mmhg.

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