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Lecture 3

NPB 168 Lecture Notes - Lecture 3: Peritubular Capillaries, Renal Physiology, Roads In The United Kingdom

4 pages95 viewsSpring 2016

Department
Neurobiology,Physio & Behavior
Course Code
NPB 168
Professor
Liets Lauren
Lecture
3

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NPB168 Lecture 3
5 liters of blood circulated fully in minute
Primary route of elimination is urine
oSome alcohol removed in breath (why breathalyzer works)
Millions of nephron in kidney, nephron is functional unit of kidney
Whatever ends in peritubular capillary stays in the body, whatever ends in kidney tubule leaves
the body.
Tubular reabsorption and tubular secretion are tightly controlled.
Metabolism BYP1-3
Metabolic Induction – drug administration leads to an increase in the activity or availability of its
own hepatic enzymes
Metabolic inhibition – drug administration leads to a decrease in the activity or availability of
hits own hepatic enzymes
oConsequence: the pharmacological effects are increased
oEnzyme system can set itself back to normal
First Pass metabolism
oDrugs must tolerate the acidic environment of the GI tract
oDrugs must first cross cells lining the GI tract where they may come across metabolic
enzymes
oNext drugs pass through the liver – the primary metabolic site
oDrugs moved into the systemic blood undergo depot binding
Repeated Administrations: Tolerance and Sensitization
oTolerance
A state of progressively decreasing responsiveness to subsequent
administrations of the same dose of a drug
A need to increase the dose of a drug with subsequent administrations in order
to yield the same magnitude of effect
oSensitization
A state of progressively increasing responsiveness to subsequent
administrations of the same dose of a drug
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