NPB 168 Lecture Notes - Lecture 3: Peritubular Capillaries, Renal Physiology, Roads In The United Kingdom
27 Apr 2016
School
Department
Course
Professor
Document Summary
5 liters of blood circulated fully in minute. Primary route of elimination is urine: some alcohol removed in breath (why breathalyzer works) Millions of nephron in kidney, nephron is functional unit of kidney. Whatever ends in peritubular capillary stays in the body, whatever ends in kidney tubule leaves the body. Tubular reabsorption and tubular secretion are tightly controlled. Metabolic induction drug administration leads to an increase in the activity or availability of its own hepatic enzymes. Metabolic inhibition drug administration leads to a decrease in the activity or availability of hits own hepatic enzymes: consequence: the pharmacological effects are increased, enzyme system can set itself back to normal. A state of progressively decreasing responsiveness to subsequent administrations of the same dose of a drug. A need to increase the dose of a drug with subsequent administrations in order to yield the same magnitude of effect: sensitization.
