PSC 101 Lecture Notes - Lecture 20: Endocrine System, Occipital Lobe, Cell Migration
28 Aug 2018
School
Department
Course
Professor
Document Summary
Ionotropic vs metabotropic receptors: metabotropic receptors don"t open pores (ion channels); ligands bind and set off a cascade of events inside the neuron, nothing gets exchanged in the metabotropic receptors. Ionotropic receptors have binding sites on the outside; closed channel opens and has influx of ions: metabotropic receptors produce changes on the inside of the cell; takes more time, once changes take place signal can be amplified. Ionotropic receptors generally mediate rapid postsynaptic events: metabotropic takes longer but has bigger effects, metabotropic receptors don"t have ion channels; affect other channels with g-proteins. If several excitatory synapses are active at the same time the epsps they produce summate as they travel toward the axon and the axon fires. If several inhibitory synapses are active at the same time the ipsps they produce diminish the size of the epsps and prevent the axon from firing.
