BIO SCI 35 Lecture Notes - Lecture 4: Axon Hillock, Saltatory Conduction, Peripheral Nervous System

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Ligand-gated sodium channels open - the inside gets more positive. Rising phase of the action potential a. b. When reaches threshold - voltage-gated sodium channels open - since the inside got positive. Falling phase of the action potential a. b. c. Voltage-gated potassium channels open - the inside gets less positive. Hyperpolarized - more negative than resting potential - too much potassium flowed out. During this time, impossible for cell to fire again. Sodium-potassium pump brings the cell back to its resting potential. At the site where the action potential is generated, usually the axon hillock, an electrical current depolarizes the neighboring region of the axon membrane. Action potentials travel in only one direction: toward the synaptic terminals. Inactivated sodium channels behind the zone of depolarization prevent the action potential from traveling backwards. Myelination facilitates saltatory conduction of an action potential. Myelin is a cell with a lot of fat.

Related Questions

What would be most strongly affected by a drug that inhibited the opening of voltage-gated potassium channels (also known as delayed rectifiers)?

A. Falling phase of an action potential

B. Rising phase of an action potential

C. Resting membrane potential

D. Threshold for an action potential

Why does the voltage during the undershoot phase of the action potential become more negative than the resting membrane potential?

A. During the undershoot potassium ions are flowing into the cell due to the reversal of the potassium concentration gradient occurring during the action potential

B. The undershoot phase results from a delay in the activation of sodium channels, resulting in some sodium channels being open after the voltage-gated potassium channels have closed. C. The potassium conductance is higher during the undershoot than during the resting membrane potential.

D. The concentration gradient for potassium has been reversed as a result of the action potential, and the undershoot phase lasts until this the concentration gradient is restored.

silverdinosaur935

Which of the following statements is FALSE? (choose one)

A.	Voltage-gated sodium (Na+) channels open in the dendrites and cell body during a local, graded potential.

B.	During repolarization, potassium ions are leaving the cell (K+ is diffusing out of the cell), and the inside of the cell becomes more negative

C.	If someone damaged an efferent motor neuron, they could feel pain, but not respond to move away from the pain

D.	Myelin serves as electrical insulation and increases the speed at which an action potential travels along the axon

E.	Movement of ions can be excitatory (if sodium ligand-gated channels bind the neurotransmitter), or inhibitory (if potassium ligand-gated channels bind the neurotransmitter)

Tetraethylammonium (TEA) is a drug that blocks voltage-gated potassium channels. What effect would this have on an action potential?

(a)Prevent the rising phase

(b)Prevent the cell from reaching the threshold to trigger an action potential

(c)Prevent or prolong the falling phase

(d)None of the above

The hyperpolarization phase of the action potential is due to:

(a)The opening of voltage-gated Cl- channels

(b)Prolonged opening of voltage gated K+ channels

(c)The closure of resting Na+ channels

(d)Rapid inactivation of voltage-gated K+ channels

The period when it is difficult to initiate another action potential for several milliseconds due to voltage-gated sodium channel inactivation is referred to as the:

(a)Relative refractory period

(b)Absolute refractory period

(c)Resting period

(d)Hyperpolarization period

In the human central nervous system, Gap junctions are found:

(a)Only between neurons

(b)Only between astrocytes

(c)In both neurons and astrocytes

(d)In all cells

Small molecule transmitters such as acetylcholine are synthesized in:

(a)The nerve terminal

B) The cell body and transported to the nerve terminal

C) Synaptic vesicles

D) Endoplasmic reticulum

Prior to Otto Loewiâs classical experiment, which of the following was not known:

(a)stimulation of the vagus nerve slows the heart

(b)extracts of frog heart, made following vagal nerve stimulation, slow the heart

(c)some acetylcholine effects are similar to those produced by muscarine

(d)vagal nerve stimulation releases a substance which slows the heart

Which of the following is most important in determining if neurotransmission is excitatory or inhibitory?

(a)The structure of the synapse

(b)The neurotransmitter released by the presynaptic neuron

(c)The neurotransmitter receptor

(d)The strength of the stimulus

Benzodiazepines such as Valium allosterically regulate GABA receptors by:

(a)Binding at receptor sites other than the transmitter binding site

(b)Binding at the transmitter (GABA) binding site on the receptor

(c)Blocking the action of the endogenous transmitter

(d)Mimicking the action of the endogenous transmitter

GABA-A receptors are ligand-gated Cl- channels. The equilibrium potential of Cl- is -65 mV. At the neuronal resting membrane potential of -65 mV, GABA binding to the GABA-A receptor would result in the opening the Cl- channel, resulting in:

(a)no net flow of Cl- ions

(b)Cl- inflow and hyperpolarization

(c)Cl- outflow and depolarization

(d)Cl- outflow and hyperpolarization

At the mammalian neuromuscular junction, the released neurotransmitter acts on:

(a)muscarinic receptors

(b)nicotinic receptors

(c)adrenergic receptors

(d)Beta receptors

Neurotransmitters are packaged into synaptic vesicles by:

(a)endocytosis following transmitter release

(b)presynaptic membrane transporters

(c)vesicular transporters

(d)all of the above

. Which of the following are NOT types of ion channels?

Voltage-gated

(a)Ligand-gated

(b)G protein coupled receptor (GPCR)-gated

(c)Leak channels

(d)NONE of the above

NMDA receptors are unique in that their ion channel is:

(a)Ligand-gated

(b)Voltage-gated

(c)Ligand- and voltage-gated ion channels

(d)GPCR-gated

. Which of the following is INCORRECT regarding Catecholamine neurotransmitters

(a)Includes Dopamine, Norepinerphrine, and Epinephrine

(b)Contain a Catechol Ring

(c)Synthesized from Tryptophan

(d)Are produced by neurons whose cell bodies are located in the upper brainstem

The largest and most diverse group of receptors in eukaryotes is:

(a)Ligand gated receptors

(b)Glutamate receptors

(c)G-Protein coupled receptors

(d)Allosteric receptors

The most abundant G-protein coupled receptor in the brain is:

(a)Glutamate receptors

(b)Acetylcholine receptors

(c)Cannabinoid receptors

(d)Dopamine receptors

Which of the following drugs DOES NOT block voltage-gated Na+ channels

(a)Lidocaine

(b)Riluzole

(c)Reserpine

(d)Tetrodotoxin

Sarin, a nerve gas, exerts its toxicity by:

(a)blocking nicotinic receptors

(b)inhibiting choline acetyltransferase

(c)inhibiting acetylcholinesterase

(d)inhibiting voltage-gated Na+ channels

Botulinum Toxin (BoTox) interferes with transmitter release by:

(a)cleaving protein(s) involved in transmitter release

(b)blocking voltage-gated Ca2+ channels

(c)blocking voltage-gated Na+ channels

(d)blocking voltage-gated K+ channels

Atropine is:

(a)An agonist of the acetylcholine ionotropic receptor

(b)An antagonist of the acetylcholine ionotropic receptor

(c)An agonist of the acetylcholine metabotropic receptor

(d)An antagonist of the acetylcholine metabotropic receptor

BIO SCI 35 Lecture Notes - Lecture 4: Axon Hillock, Saltatory Conduction, Peripheral Nervous System

BIO SCI 35 Full Course Notes

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