BIO SCI 37 Lecture Notes - Lecture 12: Congenital Heart Defect, Hypotonia, Karyotype
1 May 2017
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Lecture 12: animal models//midterm 2: green fluorescent protein is what causes jellyfish to glow in the dark. Transgenic animal models are genetically modified to have their genome altered. Some examples of this would be taking the protein that gives jellyfish their fluorescent quality and inserting it into the genome of another animal such as a rat. It is localized in chromosome 21 the chromosome that people with down syndrome have an extra copy of this chromosome. Because overexpression of app exists due to the duplication of the 21 chromosome, people with down syndrome are more likely to get. Alzhei(cid:373)er(cid:859)s. alzhei(cid:373)er(cid:859)s is a (cid:373)ultifa(cid:272)torial disease, (cid:449)hi(cid:272)h is (cid:449)h(cid:455) (cid:449)e sa(cid:455) (cid:858)(cid:373)ore likel(cid:455)(cid:859) rather than certain. Types of animal models: organism specific (invertebrate, vertebrates) *look i(cid:374)to e(cid:454)a(cid:373)ples of this a(cid:374)d do(cid:374)(cid:859)t (cid:272)o(cid:374)fuse it (cid:449)ith the defi(cid:374)itio(cid:374) of (cid:862)(cid:373)odel orga(cid:374)is(cid:373)s(cid:863, disease specific (multiple models per disease): an example would be trying to induce.
