BIO SCI 38 Lecture Notes - Lecture 22: Excitotoxicity, Knitting, Memantine
5 Sep 2016
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Document Summary
The 900 pound gorilla in the room: dementia. Dementia: impaired memory, impairment in at least one other cognitive domain, impairs social or occupational functioning, gradual onset and continual decline. Vascular dementia (vad) widespread damage from mini strokes . Caused by blockages in the brain"s blood supply leading to widespread, diffuse damage and cognitive loss. The second most common form of dementia (behind alzheimer"s) May cause or exacerbate alzheimer"s (complicates diagnosis as vascular contributes to ad) Risk factors: high blood pressure, diabetes, high cholesterol, family history of heart problems, obesity, smoking. Frontotemporal dementia (ftd) frontal and temporal damage. Clinical syndrome associated with shrinkage of the frontal and temporal lobes. Dementia with lewy bodies (dlb) abnormal protein aggregations. Presence of lewy bodies (alpha-syncline neuronal inclusion bodies) Similar to ad in terms of cognitive features and can sometimes be confused with it, however it also includes other symptoms: bradykinesia (slow motion) and rigidity (similar to parkinson"s, recurrent and well-formed hallucination.
