BIO SCI 45 Lecture Notes - Lecture 12: Enzyme, Urethra, Breastfeeding
13 Oct 2016
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Biological plausibility establishing cause and effect relationship between biological agent + disease. Epidemiological causation statistical association between observed risk factor + disease. Fragile outside of body: room temperature, water. Lab procedures needed to group hiv outside of body. Hiv present in certain cells: macrophages white blood cells (cleaners of tissue) Long term reservoirs: blood, uro-genital areas of vagina and penis, anus, lungs, and throat: t-helper lymphocytes host immunity cells, langerhans cells. Mucosal surfaces and below surface of skin. These cells are present in some bodily fluids and secretions and in different concentrations. Hiv increases in areas with high numbers of live cells. Degree of hiv infectivity: very high: blood, semen, vaginal/cervical secretion, high: breast milk, low: saliva, tears, none: perspiration/sweat, urine, feces. Must survive long enough to pass to susceptible person through infection of cells. Hiv particle is inactivated by: exposure to air or light, contact with soap and water. Hiv requires virus receptors on cell surface.
