BIO SCI 97 Lecture 20: Lecture 20 Notes

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Heritability was developed to help measure the proportion of phenotypic variation that is due to genetic variation. It is a measure of the degree to which genetic differences contribute to the phenotypic variation of a trait. Heritability values are accurate only for the environment and population in which they are measured. Heritability for a given trait in a population can change. High heritability does not preclude environmental factors. Narrow sense (h^2) estimates the proportion of phenotypic variation that is due to. Broad sense heritability (h^2) - estimates the proportion of phenotypic variation that is additive genetic variation ( = va/ vp) due to total genetic variation (=vg/vp) Both expressed as proportions ranging in magnitude from 0 - 1. 0. Heritability is very difficult to measure accurately in human populations, but phenotypic variation in twins can provide some insight. For mz twins, vp = ve (phenotypic variance = environmental variance) Monozygotic twins - identical twin that share 100% of their alleles.

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