BIO SCI D103 Lecture Notes - Acetaldehyde Dehydrogenase, Missense Mutation, Oxidative Phosphorylation
18 Mar 2014
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Document Summary
Cancer i. i. ii. i. ii. i. ii. i. Involves multiple rounds of mutation and natural selection. Too little instability - can"t evolve into cancer cell. Receive a mutation from one of the parents. Prevents cancer cells from using proteases to spread throughout body. Wants to stop the cell from killing itself. Cluster of a mass of cancer cells, enclosed in a membrane or organ. Study of patterns and causes of diseases in humans. Cancer cells prefer to use glycolysis over oxidative phosphorylation. Bacterial-mediated inflammation = causes cancer in tgf-beta mutated rats. Tumors are caused by an accumulation of mutations. Natural selection selects for these mutated cells which are able to i. ii. Not unstable enough = not mutated enough to be cancerous. Disregard extracellular and intracellular signals of cell cycle regulations. Most common mutation occurs in glycine, 1/4 tumors, dominant. Regulates progression to cell cycle, inhibits cell cycle. Stands for transforming growth factor, inhibits cell cycle by smads.
