BIO SCI N150 Lecture 9: 9
21 Dec 2016
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Document Summary
Beta in combination to gamma cut cause toxic beta amyloids --> become insoluble and form amyloid plaques. Progressive and neurodegenerative but there are symptom relievers. Acetylcholinersterase is abundants and is used to break down extra acetycholin in neurosn by uptake, diffusion, have enzzyme break it down to be recycled and used by other parts of cells. Inhibitor that prevents acetylcholinersterase means more acetylcholine in cell. Acetylcholine is important for movement and memory and if released near hippocampus it improves memory. In dementia, massive loss of acetylcholine in hippocampus. When cells die (neurodegenerative process), no point of acetylcholine in synapse--> small treatment (tolerability varies and can have huge sideeffects). Cocktail therapies only work when the targets of the drugs are targetting something else- sometimes synergenic but sometimes causes toxicity. There is no treatment of cure for ad. Age is #1 risk factor - genetics is #2.
