CHEM 128 Lecture Notes - Aconitine, Membrane Potential, Cytosol
2 Aug 2014
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Document Summary
Toxin project target structure. Voltage gated sodium channels mediate the amount of sodium entering the cell. Aconitine is a lipid- soluble toxin which binds to site 2 of the alpha- subunit of the voltage- gated sodium channel. Site 2 is believed to be located mainly at the s6 of the domains. Blasius, a. , dubin, a. , petrus, m. , lim, b. , narezkina, a. , criado, j. , wills, d. , xia, y. , Ehlers, c. , knowlton, k. , patapoutian, a. , beutler, b. A database of mutations and phenotypes induced by enu: background. Marban, e. , yamagishi, t. , tomaselli, g. structure and function of voltage- gated sodium channels. Payandeh, j. , scheuer, t. , zheng, n. , catteral, w. the crystal structure of a voltage- gated sodium channel. Stevens, m. , peignar, s. , tytgat, j. neurotoxins and their binding areas on voltage- gated sodium channels. Wang, s. , wang, g. voltage- gated sodium channels as primary targets of diverse lipid- soluble neurotoxins.
