BIOL 178 Lecture Notes - Lecture 5: Mesonephros, Testicle, Sertoli Cell
6 Mar 2020
School
Department
Course
Professor
Document Summary
Sexual differentiation: overview: sex determination, the event that determines whether an individual will become male or female, sexual differentiation, the developmental process of becoming male or female, jost"s model of sexual differentiation. Often have mutations in sry (humans, mice: xx phenotypic males. Often have sry-containing translocation to x chromosome: ovary-determining genes: Genes in ovarian differentiation are not well understood. Folx2 - transcription factor; essential for ovarian development. Two duct systems initially present in each embryo, from gonads to urogenital sinus: wolffian ducts - can develop into male internal reproductive tract, mullerian ducts - can develop into female internal reproductive tract, wolffian ducts: If mullerian-inhibiting hormone (mih; glycoprotein from testes) is present: What determines differentiation of the external genitalia: bipotential anlagen, genital folds, genital tubercle. Anomalies of sexual differentiation: true hermaphroditism, both ovarian and testicular tissue are present in the same individual. Ovary on one side, testis on the other.
