MCB 2004C Lecture Notes - Lecture 22: Serum Amyloid A, Lysosome, Mannose
Document Summary
Very effective antimicrobial barrier - physical and chemical. Most skin infections require breach wound, burn, bite. Lysozyme - degrades peptidoglycan in bacterial cell wall tears, saliva, mucous, blood, tissue fluid, phagocytes. Lactoperoxidase - superoxide radicals saliva, milk, body tissues, phagocytes. Lactoferrin - binds iron, nutritional immunity (protection based off preventing nutrients from pathogens) saliva, mucous, milk, phagocytes. Malt, galt, salt phagocytes and immune cells underlying mucosa. Super infections - occur when antibiotics disrupt normal flora. Cause the symptoms of many viral infections. A group of ~30 proteins in blood plasma. Complements specific activity of the immune system. Increase in response to infection, inflammation, tissue damage. C-reactive protein, amyloid a, protease inhibitors, coagulation proteins, transferrin. Chemical messengers released from many types of cells. Causes some type of response in the cell sensing the cytokine. Response to local injury, irritation, microbial invasion, bacterial toxin. Opsonization ~ candy coating -- aids binding by phagocytes. Complement fragments & cytokines also act as chemoattractants.
