MCB 2004C Lecture Notes - Lecture 23: Haemophilus Influenzae, T Helper Cell, Humoral Immunity
Document Summary
Study of the immune system and immune responses. Ab remains in blood plasma, lymph, etc and protect against pathogen that stimulated them. Involves multiple cell types (macros, t-helper, cytotoxic t, etc. ) Monoclonal antibodies: purified ab very specific for single ag, made from hybridoma (hybrid of plasma cell and tumor cell). Iga monomer or dimer, 10-20% of total saliva, tears, colostrum, breast milk, mucous. Igd found on surface of b cells. (<1%) Ige role in allergic responses (<1%) Only class that can cross placenta long-lived. Antigen: any foreign substance able to stimulate ab production. Direct interaction with b cells ab. 1st signal - mig binds repeat units of ag. Agammaglobulinemia failure to produce ab in response to ag. Activate complement for ag-ab immune complexes . Materials that artificially induce immunity to a pathogen. Contains enough antigens to yield protective ab. Inactivated killed by heat or chemicals, not as good as live. Subunit - acellular, antigenic portions of pathogen.
