NUR 3125 Lecture Notes - Lecture 6: Natural Killer Cell, Mast Cell, Adaptive Immune System
Document Summary
Injury to vascularized tissues activates inflammatory response. White blood cell adherence to inner vessel walls. Because inflammatory process occurs in vascular tissue, cell components are found in blood or tissues surrounding blood vessels. Limits tissue damage/prevents spread of inflammatory response to healthy tissue. Prevents influx of microbes by diluting toxins. Initiates healing through removal of dead cells and products of inflammatory response. Self-limiting continues until threat to host eliminated. Attracted by some bacteria, compliment cascade, and histamine. Short life span at location of injury; contributes to pus. Enter site of infection after 24 hours or later. Better suited for long term defense from infection. Microorganisms may remain dormant or multiply inside macrophages. Help to limit inflammation by mediating degradation of histamine. Activated by collagen, thrombin, and platelet activating factors. Located in loose connective tissue near blood vessels. Biologically active molecules (chemotaxic factors) released from mast cells within seconds of injury. Increased blood flow to area of injury (warmth)
