NUR 3145 Lecture Notes - Lecture 3: Rifampicin, Fusobacterium, Sulfadiazine
Document Summary
Pathogens microbes that can cause disease. Pathogenicity ability of an organism to cause disease. Opportunistic infect only when body"s immune system is suppressed. Virulence quantitative measure of an organism"s pathogenicity. Invasiveness ability of a pathogen to grow rapidly and cause direct damage to surrounding tissue by shear numbers. Gram positive: thick cell wall that retains the violet color after staining (grandma with thick glasses, positively purple: staphylococcus, streptococcus, enterococcus, Escherichia, klebsiella, pseudomonas, salmonell: shape, rod, sphere, spiral. Spirilla: oxygen or no oxygen?, aerobic, anaerobic require oxygen for growth do not require oxygen for growth. Chemical produced by one microbe that can harm other microbes. Bacteriostatic: slows the growth, allowing natural body defenses to eliminate the microorganism. Ability of the organism to become unresponsive over time to the effects of an anti-infective. Destruction of the drug: produce an enzyme to destroy or deactivate the drug. Prevention of drug entry into pathogen: enzymes inactive the drug as it crosses the cell wall.
