PCB 3233 Lecture Notes - Lecture 10: Mannose, Phagolysosome, Cell Nucleus

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12 Feb 2017
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Adaptive 4 days to when the disease is eradicated. Receptors that recognize self and non-self: nk cells and macrophages. Limited innate receptors but pathogens have same types of surface molecules so it works. Gram negative and lps no matter the genus can be recognized by macrophages. Macrophages recognized cell-surface carbs on bacteria but not on human cells. Nk cells recognize changes at surface of human cells caused by virus. Resident in tissues (a lot in connective tissue) Linings of gi, respiratory tract, lung alveoli, liver. Enhance phagocytosis > more ef cient using macrophage surface receptors. C3b is ligand (molecule that produces signal by binding to proteins) for macrophage cr1. Pathogen c3b surface fragments + degraded by factor i > ic3b > now a ligand for macrophages cr3 and cr4 receptors. Combination of opsonization by complement and phagocytosis by macrophages. Pathogens have surface components but human cells don"t. Cr3 and cr4 recognize ic3b and other ligands:

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