EDUC 132 Lecture Notes - Lecture 1: Electroencephalography, Proband, Autism Spectrum
Document Summary
Autism is linked to genes as well as the environment we are not sure yet. Asd prevalence: 5x more common in boys than girls rates are lower in minority ethnicities. Because of diagnostic bias, they are often diagnosed with things like adhd first: more children diagnosed by age 3. Genes: monozygotic twin risk is 35-96, silbing of child with asd risk is 5-25, rate variants are often causative. Environmental (anything beyond genetic mutation: parental age at time of conception. Inutero exposures (drug, infection: other? (air pollution, medication exposure, freeway proximity, maternal nutrition, not just vaccines, consensus statement: favoring rejection of a causal relationship between thimerosal-containing vaccines and autism , so nothing links vaccines and autism. Asd is a heritable disorder: monozygotic twins 60-70% concordance, dizygotic twins 5-10% concordance, recurrence risk in siblings: about 10% (higher if proband is female, recurrent rate >33% if more than one affected child.
