GE CLST 73B Lecture Notes - Lecture 12: Substantia Nigra, Basal Ganglia, Pyramidal Tracts
29 Oct 2018
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Document Summary
Most prevalent of the basal ganglia diseases. Loss of dopamine neurons in substantia nigra. This causes us to lose dopamine in the striatum. Genetic disorder which leads to deterioration of parts of striatum. Affected the basal ganglia but not cortex. Led to discrimination between a motor cortex system (pyramidal system) and a basal ganglia motor system (extrapyramidal or pre pyramidal system) Abnormal movements on one side of the body cortex thalamus striatum. Akinesia or also known as bradykinesia : lack of movement, lack of expression in face. Can"t smell very well posture is kind of destroyed, can"t swing arms when walking. If you provide additional cues, some of the symptoms can go away. If you put different strips on the ground to help them walk they will walk more normally. One man kicked his cane to help him walk by using additional sensory inputs. An age related neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra.
