LIFESCI 2 Lecture Notes - Lecture 7: Receptor Tyrosine Kinase, Blood Sugar Regulation, Insulin Receptor

• School: UCLA
• Department: Life Sciences
• Course: LIFESCI 2
• Professor: Elizabeth Roth- Johnson

Document Summary

The target cell will have a receptor for that hormone. It could be on the cell"s surface for hydrophilic hormones or lipid hormones. Leads to a change in a cell causing cell transduction: short term effects- enzyme activation, cell movement, long term effects- altered dna transcription. Glucagon (keeps blood-glucose levels in a narrow range. Signals liver cells to release glucose, when levels decrease. When levels increase, the hormone insulin signals liver cells to take up and store glucose. Comes from the pancreas but comes from different cells through the bloodstream, causing the liver to breakdown stored glycogen (glucose polymer, glycosidic linkages), liver is a main store of glycogen. Receptor tyrosine kinase (dimerization)- protein kinases bind atp adp + 3 amino acids that may have a phosphate group attached to it, tyrosine, serine, and threonine (can be phosphorylated on the amino acid side chain). (pi = po4.