LIFESCI 2 Lecture Notes - Lecture 26: Cytotoxic T Cell, Mast Cell, Granzyme

• School: UCLA
• Department: Life Sciences
• Course: LIFESCI 2
• Professor: Arnold, A.P., Esdin, J.

Document Summary

Protects against foreign substances without having to recognize their identity. Skin(keratin), fibrous layer of eyes, mucous membrane of ears, mucous membrane of respiratory, digestive system & reproductive system: chemical barriers. Sebum: oily acidic substance released from sebaceous glands, messes pathogen"s osmolarity. Lysozymes: enzymes secreted from the mucous membranes, e. g. in tears. Cilia, saliva, sweat, mucus, macrophages in lungs, hcl in stomach. Pluripotent hematopoietic stem cells -> myeloid or lymphoid cells. Neutrophils: most abundant phagocytic cells, release cytokines, vasodilators and chemotaxins(communication) Monocytes inside blood vessels/macrophages at site of infection. Mast cells thruout connective tissues (not in blood) Release histamine and other chemicals involved in inflammation. Transform into plasma cells and release antibodies into the circulation. Form memory cells: specific cells that remember pathogen. Bind to pathogens & punch holes on them using enzymes. Release perforin and granzyme induce apoptosis: reflexes (sneeze, cough) Nonspecific immune response (cut/injury thru skin: phagocytosis and recruitment.