MCD BIO 165A Lecture Notes - Lecture 13: Asymmetric Cell Division, Spindle Apparatus, Differential Signaling
15 Dec 2016
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Due to localization of specific proteins to specific areas of membrane: localization uses cytoplasmic proteins and polarized vesicle transport. Function depends on this, since secretion will be one way only. Requires subcompartmentalization of signaling events in cytosol. Branched actin: arp 2/3, cofilin, wasp polarize the cell! Actin mf bundles contract, pull trailing edge forward to keep up with rst of the cell. Cannot coordinate directed cell migration w/o front-rear polarity. Depends on orientation, positioning, morphology of mitotic spindle: heterotrimeric g proteins regulates this. Retain one cell as stem cell, other differentiates. Par2 and par3 - polarization on either side of cell. So constituency of left is not same as right -> give rise to diff cells even though identical genetically. Possible thru par segregation, changing mitotic spindle location (astral mt) and diff amt of cytosol in each cell. Polarized distribution of functions depends on coordination of three machineries involved in trafficking/distribution. Regulate protein trafficking to plasma membrane domains.
