MCD BIO CM156 Lecture Notes - Lecture 16: Tumor Suppressor Gene, Germline Mutation, Human Genetics

• School: UCLA
• Department: Molecular, Cell, and Developmental Biology
• Course: MCD BIO CM156
• Professor: Lusis

Document Summary

Covers up to today"s lecture for midterm 2. Whatever genes are in a specific region will be expressed highly within a tumor cell. Very severe changes that would not be very compatible with life. The role of germline and sporadic mutations in cancer. Mendelian disease: if the person develops a mutation in a specific spot of the gene, the children will develop the disease. Complex disease: genetic variant in germline with a strong derteminent to disease, but other factors can affect the course of the disease. Two types of cancer: familial, which accounts for 5% of cancer, and sporadic cancer, caused by a somatic mutation, occurs later in life due to the fact there is no earlier onset. Types of driver gene mutations oncogene activation: tumor suppressor gene inactivation, dna repair gene mutation (if damaged in cancer, there is no chance of repairing them, epigenetic changes.