MCD BIO CM156 Lecture Notes - Lecture 21: Eugen Bleuler, Dementia Praecox, Emil Kraepelin
17 Mar 2020
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Positive hallucinations (often auditory, command) delusions (eg reference) disorganized thoughts & speech (word salad) Negative anhedonia flat affect poverty speech (alogia) few relationships avolition poor abstract thinking stereotyped thinking. Long history of theories: divine punishment, demonic possession eg old testament, first book of. Samuel, king saul became mad" after angering god. First recognized: emil kraepelin dementia praecox" 1887. Long history of theories: sigmund freud -- attachment disorder eg to mum. Too much dopamine causes the disease to spread and cause hallucinations and delusions. Drugs of abuse another clue to causation: phencyclidine (pcp, angel dust ) ketamine ( special k ) both drugs block nmda glutamate receptors and cause positive, negative and cognitive dysfunction symptoms of sz (can cause hallucinations and delusions) Ventricular enlargement in diseased brain, ventricals have enlarged, which ended up causes the shrinkage of the brain and loss of cells. Age 6 shows major connections between the synaptic cells.
