MCD BIO CM156 Lecture Notes - Lecture 20: Adaptive Immune System, Irak1, Tank-Binding Kinase 1
17 Mar 2020
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Mechanisms for generation of variability for recognition of pathogens: antigen presentation by the major histocompatibility complex (mhc) The immune system is involved in many genetic disorders: Innate immunity (nonspecific defense mechanisms that come into play immediately or within hours of an antigen"s appearance in the body. ) Toll-like receptors: bacterial antigens (lps), double stranded rna, unmethylated dna, etc. Sickle cell globin confers sickness to malaria, ccr5delta32. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Tlrs recruit adapter proteins (proteins that mediate other protein- protein interactions) within the cytosol of the immune cell in order to propagate the antigen- induced signal transduction pathway. Adaptive immunity (refers to antigen-specific immune response. Once an antigen has been recognized, the adaptive immune system creates an army of immune cells specifically designed to attack that antigen. ) T cell receptor somatic rearrangement during t cell maturation.
