MIMG 101 Lecture Notes - Lecture 25: Helicobacter Pylori, Fecal Microbiota Transplant, Human Microbiota

• School: UCLA
• Department: Microbiology, Immunology, and Molecular Genetics
• Course: MIMG 101
• Professor: G U N S A L U S& B R A D L E Y

Document Summary

Virulence: measure of pathogenicity by cell number eliciting pathogenic response in a given time. Provide nutrients, have constant ph, have constant temp. Moist environment for growth: sebaceous glands = pro microbial, provides lipids -> prevents drying, apocrine glands = anti microbial, secrete lysozyme, lactic acid that kill bacteria. Saliva has anti microbial agents: lysozyme peptidoglycan cleavage, lactoperoxidase. Plaque: acidic glycoproteins from saliva coat teeth + sugars fermented to lactic acid, streptococcus mutans colonizes, filamentous fusobacterium thicken plaque, anaerobic actinmyces grow in thick plaque. Aids in vitamin b12, k synthesis + modifies bile acids. Clostridium difficile: fecal transplant to cure, 94% effective compared to 31% antibiotics. Microbes prevent colonization by others respiratory tract. General or specific molecules on host used to adhere specific molecule interaction: then can initiate infection i. e. cd66 marker on urogenital epithelial cells used by gonorrhoeae opa protein.