NEUROSC M101C Lecture Notes - Lecture 3: Saccharin, Adipocyte, Natural Trumpet
Document Summary
Diabetics overeat due to high blood sugar but have impaired ability to utilize glucose in the brain => glucose cannot be utilized to induce situation (e. g. in vmh, where glucoreceptors are) De ciency => initiates start signal => initiates a correction response (food-motivated behavior, food consumption) => sensory detector detects changes in energy/nutrient levels and issues a stop signal to cease food-motivated behavior/food consumption. Gabaergic projections from bnst to glutamatergic cells in the lh. Orexin r1 antagonist decreases progressive ratio responding for food. Increase activity of orexin neurons and likelihood of ring. Ghrelin increases/ghrelin r antagonist decreases pr responding for food. Satiety signals - phasic, short-acting and generated as calories and nutrients enter body. Adiposity signals - long-acting proportional to stored-up energy, long-term inhibition of feeding. Act by either: blocking appetite stimulation or potentiating action of satiety signals. Glutamatergic cells of lh inhibit feeding behavior.
