DIET 4415 Lecture Notes - Lecture 31: Bariatric Surgery, Mendelian Inheritance, Online Mendelian Inheritance In Man
Document Summary
Micro rnas - small non-coding rnas that interfere with translation of genes into protein (ex. Dropping a bomb on protein translation: definitions, penetrance, monogenetic, pleiotropy, epigenetics, phenotype, omim (online. Mendelian inheritance in man); genome wide association study. Penetrance: the proportion of individuals carrying a particular variant (or allele) of a gene (the genotype) that also express an associated trait (the phenotype). In medical genetics, the penetrance of a disease-causing mutation is the proportion of individuals with the mutation who exhibit clinical symptoms. Pleiotropy: one gene being responsible for many phenotypes. Phenotype: set of observable characteristics resulting from interactions of genotype with environment. Omim (online mendelian inheritance in man): catalog of human genes & their corresponding phenotypes. Genome wide association study: observational study of a set of genetic variants in different individuals to see if any variant is associated with a trait.
