MCB 2000 Lecture Notes - Lecture 24: Pyrophosphate, Starch, Glycogen Synthase
Document Summary
Consequences of uncoupling: excessive oxygen consumption. Utilization of substrate; electron transport still occurs but no proton gradient and no atp formed: energy is dissipated as heat, uncoupling of oxidative phosphorylation can have important physiological bene ts. Important for generating heat: hibernating animals, plants emerging from snow in the spring, thermogenin (ucp-1) in brown adipose tissue (has more mitochondria, is more metabolically active) in infants, pet-ct scan. Measures uptake of radio labeled non metabolizable analog of glucose, 18f- Brown adipose tissue not activated in obese people. Cold stress will activate brown adipose tissue. Glycogen and triglycerides -> stored energy reserves to tap into during times of high demand or need. Advantage of storing glucose as a polysaccharide: glucose is stored as glycogen in animals, glycogen has a fraction of the osmotic pressure associated with an equivalent number of glucose molecules. !1: simple sugars cannot be broken down into simpler sugars under mild conditions.
