MCB 2210 Lecture Notes - Lecture 20: Cytosol, Perforin, Death Domain
3 Apr 2016
School
Department
Course
Professor
Document Summary
Cells age old cells have different characteristics than young ones. Immortalized" cell lines can die too: but cell death is not always bad. In fact, cell death plays a crucial role in animal development, in the function of the immune system, and in the prevention of cancer: cells can die by several mechanisms: Necrosis refers to premature death due to infection or injury. Apoptosis is a form of programmed cell death (cell suicide). This process is sometimes influenced by an intracellular degradation mechanism termed autophagy (self-eating). Phagocytosis involves one cell (a phagocyte like a macrophage) eating" a dying cell (such as an apoptotic or infected cell). (phagocytes function to kill free-living bacteria as well) Telomeres the physical ends of linear chromosomes that consist of tandem arrays of a short. In fact, depletion of telomerase in hela cells using rnai causes them to stop growing within a month.
