MCB 4211 Lecture Notes - Lecture 7: Fas Receptor, Glossary Of Ancient Roman Religion, Alpha Beta Gamma
18 Sep 2016
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Cd4 positive cells & cd8 positive cells. Experiment that shows positive selection: take mouse that is mhc ab heterozygote, transplant bone marrow into two diff kind of recipients- mhc a, Mhc b: lethally irradiate which kills off all rapidly dividing cells. Includes immune response= immunocomprimised: so that transplanted bone marrow will emigrate to thymus and repopulate. October 15 notes t cells can have different reactivity. More flexibility in what t cell receptor will recognize. T cells go into surrounding tissues, into blood and trafficked around. Wanders through tissues if encounters antigen presenting cell with mhc class 2 plus peptide it can bind with it will encounter and become activated. Will begin to secrete hemotaptic factors to recruit more cells. Major classes of t cells: helper t cell- cd4 positive. When na ve have large nucleus to cytoplasm ratio. As become activated to lymphoblast cytoplasm becomes larger. Th2: cytotoxic t lymphocyte- cd8 positive.
