MCB 4211 Lecture Notes - Lecture 1: Autocrine Signalling, Apoptosis, Clonal Anergy
5 Sep 2016
School
Department
Course
Professor
Document Summary
Jenner 1798: wanted to transfer resistance to small pox from milkmaids to other people, inserted ground cow pox into young man and infected with small. Koch 1891: delayed reaction dth vs. tuberculin. Bordet 1895: compliment + ab + bacteria = lysis. Immune system: system that signals self from non-self. Signal molecule: engages a receptor- something happens, antigen. Something that can recognized by a receptor. Antigen engages antibody- smallest unit that is recognized as non self. Specific lymphocyte has an antibody on its surface as a y shaped molecule, antigen binds to both arms of y. Binding event causes signal transduction cascade and cell does something different. Plasma cell- large cell that has a lot of endoplasmic reticulum that can synthesize and secrete antibodies. Other outcomes can cause cell suicide- apoptosis. Allergies- lowering severity by repetitive exposure to allergen. Small nuances of molecular shape that immune system is able to recognize.
