NURS 3110 Lecture 7: Lecture 7

12 views2 pages
7 Feb 2017
School
Department
Course

For unlimited access to Class Notes, a Class+ subscription is required.

Gram and Bacilli (Rods)
Endotoxins are more widespread
Exotoxins are specific
Spore forming
Might find predominantly spores outside the body
Could look like a mix
Bacillus anthracis (anthrax) - sporeforming
Pathogenesis
Primarily disease of animals, humans rarely affected
Spores enter via injured skin or mucosa
Necrotic ulcer with edema
Ex: imported goods → inhalation: wool sorters (disease hemorrhagic
pneumonia)and leather
Hemorrhagic = induce bleeding
Pulmonary - breathing organism in and getting infection
Necrotic ulcer - localized infection developed by tough (skin dying/black)
Anthrax toxin
Travels in the blood and engulfed by macrophages
Causes massive macrophage death
Infection, lungs
Agent of biological warfare
Specimens: fluids, pus from lesions, sputum, blood
Mediastinal widening of lymph node = inflammation of lymph nodes
Treatment / Control
Treat with penicillin, tetracycline, ciprofloxacin - give early
Prevent by vaccinating, dispose of animal carcass properly
Gas hides, hair, bone products with ETO to kill SPORES
Vaccine
Purified toxoid
6 inoculations over 1.5 years (5 different shots then need annual booster)
Used for military personnel who are at high risk of exposure
Bacillis cereus - sporeforming
Food poisoning (heat stable exotoxin) in rice, potato, meat
Heated will remain stable
Spores survive short periods of cooking, reheating, germinate at room
temp
Enterotoxin has weak pathogenicity in healthy individuals
Infections in immunocompromised, intubated individuals, drug addicts
Eye infections associated with trauma, surgery
Alcohol does not kill spores!
Clostridium perfringens - sporeforming
Problems with vascular flow
Diabetic patients
Lack blood flow and O2 delivery
Strict anaerobe (does NOT like O2 environment)
Catalase negative
Toxins
Toxins that help spread infection - gas gangrene
find more resources at oneclass.com
find more resources at oneclass.com
Unlock document

This preview shows half of the first page of the document.
Unlock all 2 pages and 3 million more documents.

Already have an account? Log in

Get access

Grade+
$10 USD/m
Billed $120 USD annually
Homework Help
Class Notes
Textbook Notes
40 Verified Answers
Study Guides
1 Booster Class
Class+
$8 USD/m
Billed $96 USD annually
Homework Help
Class Notes
Textbook Notes
30 Verified Answers
Study Guides
1 Booster Class