NURS 3110 Lecture Notes - Lecture 10: Leprosy, Immunocompetence, Opportunistic Infection
Document Summary
Elderly and immunocompromised = risk for active tb. Multidrug therapy because want to target cellular envelope and portions of mycobacteria. May develop resistance to one drug but can die from another drug. As organism gets into lymphatic infections process spread to various organ systems. Susceptibility of the exposed person (hiv, age, homeless) Environmental factors that affect the concentration of m. tb organisms. Older test = concentrated filtrate of broth in which tb have grown for 6 weeks. Ppd (purified protein derivative) = chemical fractionation of tb. Looking to see devastation of immune system. Inject common recall antigens organisms likely to be exposed to. 1: hiv positive (not able to elicit full immune response) 2: individuals with iv drug use, new immigrants, children, lab personnel (exposed on regular basis) +2-8 weeks after infection - induration >10 mm, edema, erythema in 24-48 hours and at 72 hours. + test indicates prior contact with mycobacterial proteins (including.
