PNB 2264 Lecture Notes - Lecture 3: Coagulation, Osteoclast, Fibroblast
14 Aug 2018
School
Department
Course
Professor
Document Summary
Organized collection fo cells and non cell material. How are they characterized: cell type, physiological role, non cell material. Desmosomes: spot like adhesion, thick rivet, open intercellular path. Adherens junction: strong interlocking belt between cells, cadherin protein. Tight junctions: think of two pieces sewn together, no intercellular path. Gap junction: hole in the middle of the junction allows for movement of small molecules, still holds cells tightly. Different types of cell to cell connections must mean different functions. Given that the skin is a protective barrier, it needs tighter junctions. Stem cells: cells with a infinite ability to divide and provide differentiated daughter cells. Identifies by: morphology, location, proteins expressed on surface. Interaction between basement membrane and cell: protein-protein interactions based on ecm. This interaction causes stem cell to stay undifferentiated. Tissues are characterized by the cell type, ecm and their function. Some tissues include stem cells that can renew the tissues if damaged.
